- Neurology/Infection
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Effect of Antibiotic Prophylaxis on Early-Onset Pneumonia in Cardiac Arrest Patients Treated with Therapeutic Hypothermia
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Soo Jung Kim, Jung Kyu Lee, Deog Kyeom Kim, Jong Hwan Shin, Ki Jeong Hong, Eun Young Heo
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Korean J Crit Care Med. 2016;31(1):17-24. Published online February 29, 2016
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DOI: https://doi.org/10.4266/kjccm.2016.31.1.17
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 Abstract
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- Background:
Infectious complications frequently occur after cardiac arrest and may be even more frequent after therapeutic hypothermia. Pneumonia is the most common infectious complication associated with therapeutic hypothermia, and it is unclear whether prophylactic antibiotics administered during this intervention can decrease the development of early-onset pneumonia. We investigated the effect of antibiotic prophylaxis on the development of pneumonia in cardiac arrest patients treated with therapeutic hypothermia.
Methods
We retrospectively reviewed the medical records of patients who were admitted for therapeutic hypothermia after resuscitation for out-of-hospital cardiac arrest between January 2010 and July 2015. Patients who died within the first 72 hours or presented with pneumonia at the time of admission were excluded. Early-onset pneumonia was defined as pneumonia that developed within 5 days of admission. Prophylactic antibiotic therapy was defined as the administration of any parenteral antibiotics within the first 24 hours without any evidence of infection.
Results
Of the 128 patients admitted after cardiac arrest, 68 were analyzed and 48 (70.6%) were treated with prophylactic antibiotics within 24 hours. The frequency of early-onset pneumonia was not significantly different between the prophylactic antibiotic group and the control group (29.2% vs 30.0%, respectively, p = 0.945). The most commonly used antibiotic was third-generation cephalosporin, and the class of prophylactic antibiotics did not influence early-onset pneumonia.
Conclusion
Antibiotic prophylaxis in cardiac arrest patients treated with therapeutic hypothermia did not reduce the frequency of pneumonia.
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Citations
Citations to this article as recorded by  - Hypothermia as a potential remedy for canine and feline acute spinal cord injury: a review
Igor Šulla, Slavomír Horňák, Vladimír Balik
Acta Veterinaria Brno.2022; 91(2): 189. CrossRef - Prophylactic antibiotic use following cardiac arrest: A systematic review and meta-analysis
Keith Couper, Ryan Laloo, Richard Field, Gavin D. Perkins, Matthew Thomas, Joyce Yeung
Resuscitation.2019; 141: 166. CrossRef - A review of novel trends in management of canine spinal cord injury
Igor Šulla, Slavomír Horňák, Valent Ledecký, Vladimír Balik
Acta Veterinaria Brno.2019; 88(2): 207. CrossRef - Management of post-cardiac arrest syndrome
Youngjoon Kang
Acute and Critical Care.2019; 34(3): 173. CrossRef
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